在CNP类似物赛道，Ascendis的TransCon-CNP率先实现了剂型升级。与Vosoritide不一样的设计是TransCon-CNP被一层保护分子包裹，降低了体内清除影响，延长作用时间，实现每周一次给药。非头对头临床数据显示，TransCon-CNP每年2.29厘米的增高表现也优于Vosoritide。
They’re also known as CvRDTs (“Cv” standing for “convergent”) and CmRDTs (“Cm” standing for “commutative”), respectively, although I think “state-based” and “operation-based” are the preferred terms. ↩
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Now let’s look at state:
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